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vildagliptin 50mg + Metformin 500mg


Vildagliptin 50mg + Metformin 500mg is a combination medication used to treat type 2 diabetes. This combination is effective because it targets high blood sugar in multiple ways. Vildagliptin works by inhibiting the enzyme DPP-4, which leads to an increase in incretin hormones. These hormones help regulate insulin production and reduce the amount of glucose produced by the liver. Metformin, on the other hand, decreases the liver’s production of glucose and increases the sensitivity of muscle cells to insulin, which helps the body use glucose more effectively.

Side Effects:-

  • Gastrointestinal Issues: Common side effects include nausea, vomiting, diarrhea, and stomach pain. These symptoms usually improve as your body gets used to the medication.
  • Hypoglycemia: Although less common with this combination, there is a risk of low blood sugar, especially when taken with other diabetes medications. Symptoms of hypoglycemia include sweating, shakiness, dizziness, and confusion.
  • Headache and Dizziness: Some patients may experience headaches or dizziness. If these symptoms persist, it is important to consult a healthcare provider.
  • Lactic Acidosis: Metformin can rarely cause a serious condition called lactic acidosis. Symptoms include muscle pain, breathing difficulties, and severe stomach pain. This condition requires immediate medical attention.
  • Pancreatitis: Vildagliptin may increase the risk of pancreatitis. Symptoms include severe abdominal pain, nausea, and vomiting. Seek medical help if these occur.
  • Vitamin B12 Deficiency: Long-term use of metformin can lead to vitamin B12 deficiency. Regular monitoring of vitamin B12 levels is recommended.


This medication is indicated for adults with type 2 diabetes who have not achieved adequate blood sugar control through diet and exercise alone. It is especially useful for patients who need additional medication to manage their blood sugar levels. Vildagliptin 50mg + Metformin 500mg can be used as an initial therapy in patients with high blood sugar levels or as an add-on therapy for those not adequately controlled with metformin alone or other diabetes medications.

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