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vildagliptin 50mg + Metformin 1000mg


Vildagliptin 50mg + Metformin 1000mg is a combination medication used to manage type 2 diabetes mellitus. This combination works by utilizing the complementary mechanisms of both drugs. Vildagliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which increases the levels of incretin hormones, leading to enhanced insulin release and reduced glucagon levels. Metformin decreases glucose production in the liver, improves insulin sensitivity, and enhances glucose uptake by muscles. Together, they help to effectively control blood sugar levels.

Side Effects:-

  • Gastrointestinal Discomfort: Common side effects include nausea, diarrhea, and abdominal pain. These symptoms often diminish over time as the body adjusts to the medication.
  • Hypoglycemia: There is a risk of low blood sugar, especially when taken with other antidiabetic medications. Symptoms include sweating, shakiness, dizziness, and confusion.
  • Headache and Dizziness: Some patients may experience headaches or dizziness. If these symptoms persist or worsen, consulting a healthcare provider is advised.
  • Lactic Acidosis: Though rare, metformin can cause lactic acidosis, a serious condition. Symptoms include muscle pain, breathing difficulties, and stomach pain. Immediate medical attention is required if these occur.
  • Pancreatitis: Vildagliptin may increase the risk of pancreatitis. Symptoms include severe abdominal pain, nausea, and vomiting. Patients should seek immediate medical help if these symptoms appear.
  • Vitamin B12 Deficiency: Long-term use of metformin can lead to vitamin B12 deficiency. Regular monitoring of vitamin B12 levels is recommended.

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