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SITAGLIPTIN 50 mg + Metformin 500 mg


Sitagliptin 50 mg + Metformin 500 mg is a combination medication used to treat type 2 diabetes mellitus. It contains two active ingredients: sitagliptin, which belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, and metformin, a biguanide. This combination helps control blood sugar levels in individuals with type 2 diabetes by different mechanisms. Sitagliptin increases insulin secretion and decreases glucagon levels, while metformin improves insulin sensitivity and reduces glucose production in the liver.

Side Effects:-

  • Hypoglycemia: Taking Sitagliptin 50 mg + Metformin 500 mg may lead to hypoglycemia, especially when used with other antidiabetic medications. Symptoms include sweating, shakiness, confusion, and hunger.
  • Gastrointestinal Upset: Common side effects of this combination include stomach upset, nausea, vomiting, diarrhea, or abdominal discomfort. These effects are usually mild and temporary.
  • Upper Respiratory Tract Infections: Some individuals may experience upper respiratory tract infections such as the common cold, sore throat, or nasal congestion while taking this medication. These infections are typically mild and resolve on their own.
  • Headache: Headaches are reported by some patients as a side effect of Sitagliptin 50 mg + Metformin 500 mg. They are usually mild and transient.
  • Lactic Acidosis: Although rare, metformin, one of the components of this medication, may cause a serious side effect called lactic acidosis. Seek immediate medical attention if you experience symptoms such as muscle pain, weakness, difficulty breathing, or stomach discomfort.


Sitagliptin 50 mg + Metformin 500 mg is indicated for the management of type 2 diabetes in adults. It is prescribed to improve glycemic control when diet and exercise alone are not sufficient. This combination medication helps lower fasting and postprandial (after meal) blood sugar levels, thereby reducing the risk of complications associated with diabetes.

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