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Methylprednisolone is a corticosteroid medication used to treat a variety of conditions. Here are its main uses:

  • Inflammatory Conditions: Methylprednisolone is prescribed to reduce inflammation in conditions such as arthritis, lupus, allergic reactions, and skin disorders like eczema and psoriasis. It works by suppressing the immune system’s inflammatory response.
  • Allergic Reactions: It is used to treat severe allergic reactions (anaphylaxis) and allergic conditions like allergic rhinitis or hay fever when other treatments are ineffective.
  • Autoimmune Disorders: Methylprednisolone helps manage autoimmune diseases such as rheumatoid arthritis, lupus, and inflammatory bowel disease (IBD) by suppressing the immune system’s overactivity.
  • Respiratory Conditions: It may be prescribed for severe asthma attacks, chronic obstructive pulmonary disease (COPD), and other respiratory conditions to reduce airway inflammation and improve breathing.
  • Cancer Supportive Care: Methylprednisolone is used in cancer patients to reduce inflammation, manage side effects of chemotherapy, and alleviate symptoms like nausea and vomiting.

Side Effects:-

While methylprednisolone is effective, it may cause some side effects. Common side effects include:

  • Increased Risk of Infections: Methylprednisolone can suppress the immune system, leading to an increased risk of infections. Watch for signs of infection such as fever, sore throat, and cough.
  • Gastric Irritation: It may cause stomach upset, indigestion, or gastric ulcers, especially when taken without food or for a prolonged period.
  • Fluid Retention: Some individuals may experience fluid retention, leading to swelling in the legs or ankles.
  • Mood Changes: Methylprednisolone can affect mood and may cause mood swings, anxiety, or irritability, especially at higher doses.
  • Insomnia: Difficulty sleeping or insomnia may occur, particularly when methylprednisolone is taken later in the day.
  • Increased Appetite: Some people may experience increased appetite and weight gain while taking methylprednisolone.
  • High Blood Sugar: It can raise blood sugar levels, so individuals with diabetes need to monitor their blood sugar closely.


Methylprednisolone 500 mg is indicated for the treatment of various inflammatory conditions, allergic reactions, autoimmune disorders, severe asthma attacks, and supportive care in certain cancer patients. It is administered orally or intravenously under medical supervision and is typically used for short periods at the lowest effective dose to minimize side effects.

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