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Methylprednisolone 125 mg is a corticosteroid medication used to treat various conditions. Here are its main uses:

  • Inflammatory Conditions: It is prescribed to reduce inflammation associated with conditions such as arthritis, tendonitis, bursitis, and inflammatory bowel disease (IBD) like ulcerative colitis and Crohn’s disease.
  • Allergic Reactions: Methylprednisolone 125 mg is used to treat severe allergic reactions, including anaphylaxis, as well as allergic conditions like allergic rhinitis, allergic dermatitis, and drug allergies.
  • Skin Disorders: It helps manage skin conditions such as eczema, psoriasis, and allergic dermatitis by reducing redness, swelling, and itching.
  • Respiratory Conditions: This medication may be used to treat severe asthma attacks, chronic obstructive pulmonary disease (COPD), and allergic bronchitis by reducing airway inflammation.
  • Autoimmune Diseases: Methylprednisolone is used to suppress the immune system in autoimmune diseases like lupus, rheumatoid arthritis, and multiple sclerosis to alleviate symptoms and prevent disease progression.

Side Effects:-

  • While methylprednisolone is effective, it may cause some side effects. Common side effects include:
  • Increased Risk of Infections: Methylprednisolone can weaken the immune system, making individuals more susceptible to infections such as colds, flu, and urinary tract infections.
  • Gastric Irritation: It may cause stomach upset, indigestion, or gastric ulcers, particularly when taken without food or for a long time.
  • Fluid Retention: Some people may experience swelling in the legs or ankles due to fluid retention.
  • Mood Changes: Methylprednisolone can affect mood and may cause mood swings, anxiety, or depression, especially at higher doses or with long-term use.
  • Insomnia: Difficulty sleeping or insomnia may occur, particularly when taking methylprednisolone later in the day.
  • Increased Appetite: Some individuals may experience increased appetite and weight gain while taking methylprednisolone.
  • High Blood Sugar: It can raise blood sugar levels, so individuals with diabetes need to monitor their blood sugar closely.


Methylprednisolone 125 mg is indicated for the treatment of various inflammatory conditions, allergic reactions, skin disorders, respiratory conditions, and autoimmune diseases. It is available in oral tablets, injections, or intravenous formulations and should be used as directed by a healthcare professional to minimize side effects and maximize benefits.

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