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Glimepiride 2 mg+ pioglitazone 15mg +Metformin 500mg SR


Glimepiride 2 mg + Pioglitazone 15 mg + Metformin 500 mg SR is a combination medication used to treat type 2 diabetes mellitus. It combines three different drugs to help control blood sugar levels. Glimepiride increases insulin production from the pancreas, Pioglitazone improves the body’s sensitivity to insulin, and Metformin reduces the amount of glucose produced by the liver and improves insulin sensitivity. Together, these actions help to lower blood sugar levels in patients with type 2 diabetes.

Side Effects:-

  • Hypoglycemia: One of the main side effects of Glimepiride is hypoglycemia, or low blood sugar. Symptoms can include sweating, shakiness, dizziness, hunger, and confusion. It is important for patients to recognize these symptoms and treat them promptly, usually with a quick source of sugar like glucose tablets or juice.
  • Gastrointestinal Issues: Metformin can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal discomfort. These symptoms are usually temporary and tend to decrease as the body adjusts to the medication.
  • Weight Gain: Pioglitazone may cause weight gain, which is primarily due to fluid retention and increased fat storage. Patients should monitor their weight regularly and report significant changes to their healthcare provider.
  • Fluid Retention: Pioglitazone can lead to fluid retention, resulting in swelling, particularly in the legs and ankles. This side effect is especially important for patients with heart conditions as it can worsen heart failure.
  • Lactic Acidosis: Metformin, although rare, can cause a serious condition known as lactic acidosis. Symptoms include muscle pain, difficulty breathing, stomach pain, dizziness, and irregular heartbeat. This risk is higher in patients with kidney or liver problems.
  • Allergic Reactions: Allergic reactions to this medication can include rash, itching, swelling, and breathing difficulties. Immediate medical attention is required if these symptoms occur.


This combination is indicated for patients with type 2 diabetes who require multiple medications to achieve adequate blood glucose control. It is particularly useful for patients whose blood sugar levels are not well controlled with diet, exercise, and monotherapy. By targeting different mechanisms involved in glucose regulation, this medication provides a comprehensive approach to managing type 2 diabetes.

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