Composition:-
Dapaglifozin 10mg + Vildagliptin 100 mg SR
Uses:-
Dapagliflozin 10mg combined with Metformin 1000mg is prescribed for the management of type 2 diabetes mellitus in adults. Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor that lowers blood glucose by preventing glucose reabsorption in the kidneys. Metformin, a biguanide, works by decreasing hepatic glucose production and enhancing insulin sensitivity. The combination helps in achieving better glycemic control, reducing HbA1c levels, and promoting weight loss in patients.
Side Effects:-
- Genital Infections: Dapagliflozin can increase the risk of genital infections such as yeast infections and urinary tract infections due to higher glucose levels in the urine. Symptoms may include itching, irritation, and unusual discharge.
- Gastrointestinal Issues: Metformin can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal discomfort. These effects are often temporary and can be minimized by taking the medication with food.
- Hypoglycemia: Although the risk of hypoglycemia is low when dapagliflozin and metformin are used alone, it can increase when combined with other diabetes medications like insulin or sulfonylureas. Symptoms include sweating, dizziness, and confusion.
- Dehydration: Dapagliflozin can cause increased urination, which may lead to dehydration. Patients should drink plenty of fluids to stay hydrated.
- Lactic Acidosis: Metformin has a rare but serious risk of causing lactic acidosis, characterized by muscle pain, respiratory distress, and abdominal pain. Immediate medical attention is required if these symptoms occur.
- Ketoacidosis: Dapagliflozin may rarely lead to diabetic ketoacidosis, a serious condition with symptoms such as nausea, vomiting, and abdominal pain. Patients should seek immediate medical attention if these symptoms appear.
Indication:-
This combination is indicated for adults with type 2 diabetes mellitus to improve glycemic control when diet, exercise, and metformin alone are not sufficient. It is particularly useful for patients who require a stronger treatment to manage their blood sugar levels effectively. The combination is also beneficial for patients who have been taking metformin but need additional support to reach their blood glucose targets. It may be used as part of a comprehensive diabetes treatment plan that includes lifestyle modifications and other medications.
