Composition:-
Dapaglifozin 10mg + METOFORMIN 1000 MG + SITAGLIPTIN 100 MG
Uses:-
This combination medication is used to manage type 2 diabetes mellitus in adults. Dapagliflozin, an SGLT2 inhibitor, helps lower blood sugar by promoting the excretion of glucose through urine. Metformin, a biguanide, works by decreasing glucose production in the liver and improving insulin sensitivity. Sitagliptin, a DPP-4 inhibitor, increases incretin hormone levels, which in turn enhances insulin release and decreases glucagon levels. Together, these medications provide a comprehensive approach to lowering blood sugar levels, reducing HbA1c, and potentially aiding in weight management.
Side Effects:-
- Genital and Urinary Tract Infections: Dapagliflozin can increase the risk of genital infections such as yeast infections and urinary tract infections. Symptoms may include itching, irritation, and unusual discharge.
- Gastrointestinal Issues: Metformin commonly causes gastrointestinal side effects, including nausea, vomiting, diarrhea, and abdominal discomfort. These effects can be mitigated by taking the medication with food.
- Hypoglycemia: Although the risk is generally low, hypoglycemia can occur, especially when combined with other diabetes medications like insulin or sulfonylureas. Symptoms of hypoglycemia include sweating, dizziness, and confusion.
- Dehydration: Dapagliflozin may lead to increased urination, which can cause dehydration. Patients are advised to drink plenty of fluids to stay hydrated.
- Lactic Acidosis: Metformin carries a rare but serious risk of lactic acidosis, characterized by muscle pain, respiratory distress, and abdominal pain. Immediate medical attention is required if these symptoms occur.
- Ketoacidosis: Dapagliflozin may rarely cause diabetic ketoacidosis, a serious condition with symptoms such as nausea, vomiting, and abdominal pain. Immediate medical attention is necessary if these symptoms develop.
- Upper Respiratory Infections: Sitagliptin may increase the risk of upper respiratory infections, with symptoms including a runny nose, sore throat, and cough.
Indication:-
This medication is indicated for adults with type 2 diabetes mellitus who require improved glycemic control when diet, exercise, and either metformin, dapagliflozin, or sitagliptin alone do not suffice. It is especially beneficial for patients needing more robust blood sugar management and those who have not achieved desired results with single or dual therapy. The combination therapy is intended to help patients reach their glycemic targets more effectively.
