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Gliclazide 80mg + Metformin 500mg


Gliclazide 80mg + Metformin 500mg is a combination medication used to treat type 2 diabetes mellitus. Gliclazide belongs to a class of medications called sulfonylureas, which help increase insulin secretion from the pancreas. Metformin, on the other hand, is a biguanide that decreases glucose production in the liver and improves the body’s sensitivity to insulin. Together, these medications help control blood sugar levels more effectively than either drug alone.

Side Effects:-

  • Hypoglycemia: One of the main side effects of Gliclazide is hypoglycemia, or low blood sugar. Symptoms include dizziness, sweating, shaking, and confusion. Patients should monitor their blood sugar levels regularly and carry a source of fast-acting sugar in case of a hypoglycemic episode.
  • Gastrointestinal Issues: Metformin can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal discomfort. Taking the medication with meals can help reduce these side effects.
  • Weight Gain: Gliclazide may cause weight gain in some patients. Regular exercise and a balanced diet are recommended to help manage weight.
  • Allergic Reactions: Although rare, some patients may experience allergic reactions to Gliclazide, which can include symptoms like rash, itching, and swelling. Immediate medical attention is required if an allergic reaction occurs.
  • Lactic Acidosis: Metformin carries a rare but serious risk of lactic acidosis, a condition characterized by muscle pain, difficulty breathing, stomach pain, and dizziness. This requires immediate medical attention.


This medication is indicated for adults with type 2 diabetes who have not achieved adequate blood sugar control with diet, exercise, and single-agent therapy. It is particularly beneficial for patients who need additional help in managing their blood glucose levels. The combination of Gliclazide and Metformin is designed to provide a comprehensive approach to diabetes management by targeting different mechanisms involved in blood sugar regulation.

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